We build tools to improve the chemical understanding of microbial community function
High Resolution Mass Spectrometry
The lab extensively uses high-resolution tandem mass spectrometry for non-targeted metabolomics. We are equipped with a Q-Exactive HF LC-MS/MS system and have access to a range of other mass spectrometers in the CMFI research cluster.
For hardware development that is needed to build new mass spectrometry interfaces, micro liquid-handling and co-culture systems, we use 3D printing, laser cutting and CNC milling for rapid prototyping.
We work on the development and standardization of mass spectrometry methods, including sample preparation methods such as solid phase extraction. In addition to mass spectrometry we focus on the integration of bioactivity-based methods and microbiome model systems to add functional information to our high-throughput metabolomics pipline.
Computational Mass Spectrometry
We work closely with the developers of the GNPS and MZmine community to develop new computational approaches and scalable software solutions for mass spectrometry data analysis.